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KMID : 1132720040020020081
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Genomics & Informatics
2004 Volume.2 No. 2 p.81 ~ p.85
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No Evidence of Association of Interleukin 1A (-889) Genetic Polymorphism with Alzheimer’s Disease in Koreans
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Jhoo Jin-Hyeong
Lee Dong-Young
Kim Ki-Woong
Youn Jong-Chul
Woo Jong-Inn
Park Woong-Yang
Seo Jeong-Sun
Lee Kwang-Hyuk
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Abstract
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To examine whether the IL-1A (-889) polymorphism associates with a risk for Alzheimer’’s disease (AD) and acts interactively with the apolipoprotein (APOE) $\epsilon$4 in the development of AD, we performed genotype analyses of the IL-1A and the APOE of the 102 Korean AD patients and 200 Korean non-demented controls. We failed to detect a significant difference in genotypic and allelic frequencies of IL-1A between the AD group and control group. No overexpression of the IL-1A C/T genotype and IL-1A T allele was found when we analyzed the late-onset and early-onset patients, separately. There was no significant genetic interaction between IL-1A polymorphism and the APOE polymorphism. I n conclusion, the IL-1A polymorphism did not contribute to the development of AD independently or interactively with the APOE $\epsilon$4 allele in Koreans.
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KEYWORD
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Alzheimer’s disease (AD), Interleukin-1A (IL-1A), Koreans, association
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